My typical cross country speed is "I follow trucks" which tend to be in the 65-70 mph speed range. There is some minor efficiency gain from letting the truck handle part of the aerodynamic drag but the real savings are: (1) minimum tailgating, and (2) cost-effective block-to-block time.
It really is state dependent. If you live in Virginia your highway speeds are likely never more than 65 mph and there are no trade winds to deal with. If you lice in Texas your highway speeds are likely 80-90mph and you are often heading into 15mph winds.