SouthernDude
Active Member
https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.1c03380
"The importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. Here, we demonstrate that vaccine-breakthrough or antibody-resistant mutations provide a new mechanism of viral evolution. Specifically, vaccine-resistant mutation Y449S in the spike (S) protein receptor-binding domain, which occurred in co-mutations Y449S and N501Y, has reduced infectivity compared to that of the original SARS-CoV-2 but can disrupt existing antibodies that neutralize the virus. By tracking the evolutionary trajectories of vaccine-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations correlate strongly with the vaccination rates in Europe and America. We anticipate that as a complementary transmission pathway, vaccine-breakthrough or antibody-resistant mutations, like those in Omicron, will become a dominating mechanism of SARS-CoV-2 evolution when most of the world’s population is either vaccinated or infected. Our study sheds light on SARS-CoV-2 evolution and transmission and enables the design of the next-generation mutation-proof vaccines and antibody drugs."
In short, extremely high vaccination rates are associated with the origins and spread of covid strains that are resistant to the vaccine. If this is actually accurate, it completely vindicates what I have said earlier about mass vaccination.
Yes, this is some basic correlation study and basic correlation studies have a ton of flaws (e.g. they rarely ever truly correct for confounding variables). However, these basic correlation studies that don't adequately address confounding variables are the standard for what has "proven" that flimsy face covering requirements with no standard pore size/shape are super duper effective and that social distancing is super duper necessary, except when at BLM riots or when a state government puts people sick with covid in nursing homes.
I would love to see how the "science" loving know-it-alls would deal with the claims of this study without invalidating their standard of evidence for the aforementioned super effective and super necessary other mandates.
"The importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. Here, we demonstrate that vaccine-breakthrough or antibody-resistant mutations provide a new mechanism of viral evolution. Specifically, vaccine-resistant mutation Y449S in the spike (S) protein receptor-binding domain, which occurred in co-mutations Y449S and N501Y, has reduced infectivity compared to that of the original SARS-CoV-2 but can disrupt existing antibodies that neutralize the virus. By tracking the evolutionary trajectories of vaccine-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence and frequency of vaccine-resistant mutations correlate strongly with the vaccination rates in Europe and America. We anticipate that as a complementary transmission pathway, vaccine-breakthrough or antibody-resistant mutations, like those in Omicron, will become a dominating mechanism of SARS-CoV-2 evolution when most of the world’s population is either vaccinated or infected. Our study sheds light on SARS-CoV-2 evolution and transmission and enables the design of the next-generation mutation-proof vaccines and antibody drugs."
In short, extremely high vaccination rates are associated with the origins and spread of covid strains that are resistant to the vaccine. If this is actually accurate, it completely vindicates what I have said earlier about mass vaccination.
Yes, this is some basic correlation study and basic correlation studies have a ton of flaws (e.g. they rarely ever truly correct for confounding variables). However, these basic correlation studies that don't adequately address confounding variables are the standard for what has "proven" that flimsy face covering requirements with no standard pore size/shape are super duper effective and that social distancing is super duper necessary, except when at BLM riots or when a state government puts people sick with covid in nursing homes.
I would love to see how the "science" loving know-it-alls would deal with the claims of this study without invalidating their standard of evidence for the aforementioned super effective and super necessary other mandates.
