I'd drive it without hesitation. Get on Plugshare or ABRP and locate a charger every 120 to 160 miles or so, and allow for charging time. I tend to figure on a 20 to 30 minute stop each time. Leave with 100% charge and then use fast chargers to get to about 80%; DC fast charging above 90% isn't worth the time because charging power gets very slow as the battery fills to most of its capacity.
Recently I did a trip of a little less than half that length (Baltimore area to Charlotte and back), using US-29 for most of it which had fewer charging opportunities, and had no issues. I also regularly drive between Baltimore and Columbus, Ohio and haven't had any problems finding charging. There are plenty of chargers along I-81, I-77 and I-85. Don't plan on using just one brand of charger; I usually rely on the brand names (Electrify America, ChargePoint, EVgo, and down south, Circle K) and note that nearby dealer chargers can be used as alternates if there are any problems. Also look for hotels that offer free overnight charging.