Nothing major. I am in Marion, IA. The engine will run a lot in winter when temps are less than about 10 F and your range will be less with electric heater. I imagine your EV range might be as low as 25 mi in winter and as high as 60+ in warm weather without climate control.
My only real complaint in the midwest is the washer fluid tank is very small (like 1 L) and needs to be filled all the time in winter with the salt spray you get from the treated roads.
Preferably drive it with both a charged and discharged battery. It drives differently when the battery is discharged, but most of the time it is driven on battery for us with road trips on gas. The electric heater is very effective at heating the car within 1 minute of leaving the house. Much faster than any gas car I have driven, much faster than my Volt was too.
PS, the car is much more pleasant to drive if you install a 240V charging station in your garage. This allows preconditioning the car to get it hot or cold. Coming from an attached garage it isn't needed too much, but many people like the car at temperature before they drive.